Corticobasal degeneration explained

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Corticobasal degeneration explained 

Corticobasal degeneration explained  

Corticobasal degeneration explained

Corticobasal degeneration (CBD) is a progressive disorder characterized by nerve cell loss and atrophy of multiple areas of the brain. 

Brain cells from people with CBD often have abnormal accumulations of the protein tau. 

CBD usually progresses gradually over the course of 6 to 8 years. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body but eventually will affect both sides.

Some of the symptoms, such as poor coordination and rigidity, are similar to those found in Parkinson's disease. 

Other symptoms may include memory loss, dementia, visual-spatial problems, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, myoclonus (involuntary muscular jerks), and dysphagia (difficulty swallowing).

Death is often caused by pneumonia or other secondary problems such as sepsis (severe infection of the blood) or pulmonary embolism (a blood clot in the lungs).

There are no specific treatments available for CBD. Drugs such as clonazepam may help with myoclonus, however, and occupational, physical, and speech therapy can help in managing the disabilities associated with this disease. 

The symptoms of the disease often do not respond to Parkinson's medications or other drugs.

 

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