Multiple Sclerosis Factsheet

| General Disclaimer | Latest Health News | Homepage |

  Related Sites 

Sclerosis Explained

Multiple Sclerosis  

What is Multiple Sclerosis?

An unpredictable disease of the central nervous system, Multiple Sclerosis (MS) can range from relatively benign to somewhat disabling to devastating, as communication between the brain and other parts of the body is disrupted.  

Many investigators believe MS to be an autoimmune disease -- one in which the body, through its immune system, launches a defensive attack against its own tissues. In the case of MS, it is the nerve-insulating myelin that comes under assault. Such assaults may be linked to an unknown environmental trigger, perhaps a virus.

Most people experience their first symptoms of Multiple Sclerosis between the ages of 20 and 40; the initial symptom of MS is often blurred or double vision, red-green color distortion, or even blindness in one eye.  Most MS patients experience muscle weakness in their extremities and difficulty with coordination and balance.  

These symptoms may be severe enough to impair walking or even standing. In the worst cases, MS can produce partial or complete paralysis.  Most people with Multiple Sclerosis also exhibit paresthesias, transitory abnormal sensory feelings such as numbness, prickling, or "pins and needles" sensations.  

Some may also experience pain.  Speech impediments, tremors, and dizziness are other frequent complaints. Occasionally, people with MS have hearing loss. Approximately half of all people with MS experience cognitive impairments such as difficulties with concentration, attention, memory, and poor judgment, but such symptoms are usually mild and are frequently overlooked.  Depression is another common feature of MS.

Is there any treatment?

There is as yet no cure for MS. Many patients do well with no therapy at all, especially since many medications have serious side effects and some carry significant risks.  However, three forms of beta interferon (Avonex, Betaseron, and Rebif) have now been approved by the Food and Drug Administration for treatment of relapsing-remitting MS. 

Beta interferon has been shown to reduce the number of exacerbations and may slow the progression of physical disability. When attacks do occur, they tend to be shorter and less severe.  The FDA also has approved a synthetic form of myelin basic protein, called copolymer I (Copaxone), for the treatment of relapsing-remitting MS. 

Copolymer I has few side effects, and studies indicate that the agent can reduce the relapse rate by almost one third. An immunosuppressant treatment, Novantrone (mitoxantrone ), is approved by the FDA for the treatment of advanced or chronic MS.

While steroids do not affect the course of MS over time, they can reduce the duration and severity of attacks in some patients.  Spasticity, which can occur either as a sustained stiffness caused by increased muscle tone or as spasms that come and go, is usually treated with muscle relaxants and tranquilizers such as baclofen, tizanidine, diazepam, clonazepam, and dantrolene. 

Physical therapy and exercise can help preserve remaining function, and patients may find that various aids -- such as foot braces, canes, and walkers -- can help them remain independent and mobile.  Avoiding excessive activity and avoiding heat are probably the most important measures patients can take to counter physiological fatigue.  

If psychological symptoms of fatigue such as depression or apathy are evident, antidepressant medications may help.  Other drugs that may reduce fatigue in some, but not all, patients include amantadine (Symmetrel), pemoline (Cylert), and the still-experimental drug aminopyridine. Although improvement of optic symptoms usually occurs even without treatment, a short course of treatment with intravenous methylprednisolone (Solu-Medrol) followed by treatment with oral steroids is sometimes used.

What is the prognosis?

A physician may diagnose MS in some patients soon after the onset of the illness. In others, however, doctors may not be able to readily identify the cause of the symptoms, leading to years of uncertainty and multiple diagnoses punctuated by baffling symptoms that mysteriously wax and wane.  

The vast majority of patients are mildly affected, but in the worst cases, MS can render a person unable to write, speak, or walk.  MS is a disease with a natural tendency to remit spontaneously, for which there is no universally effective treatment.

What research is being done?

The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct research in laboratories at the NIH and also support additional research through grants to major medical institutions across the country.  

Scientists continue their extensive efforts to create new and better therapies for MS.  One of the most promising MS research areas involves naturally occurring antiviral proteins known as interferons. Beta interferon has been shown to reduce the number of exacerbations and may slow the progression of physical disability. When attacks do occur, they tend to be shorter and less severe.  

In addition, there are a number of treatments under investigation that may curtail attacks or improve function.  Over a dozen clinical trials testing potential therapies are underway, and additional new treatments are being devised and tested in animal models.


Clearinghouse on Disability Information
Special Education & Rehabilitative Services Communications & Customer Service Team
550 12th Street, SW, Rm. 5133
Washington, DC   20202-2550
Tel: 202-245-7307 202-205-5637 (TTD)
Fax: 292024507636

International Essential Tremor Foundation
P.O. Box 14005
Lenexa, KS   66285-4005
Tel: 913-341-3880 888-387-3667
Fax: 913-341-1296

Multiple Sclerosis Association of America
706 Haddonfield Road
Cherry Hill, NJ   08002
Tel: 856-488-4500 800-532-7667
Fax: 856-661-9797

Multiple Sclerosis Foundation
6350 North Andrews Avenue
Ft. Lauderdale, FL   33309-2130
Tel: 954-776-6805 888-MSFOCUS (673-6287)
Fax: 954-351-0630

National Multiple Sclerosis Society
733 Third Avenue
6th Floor
New York, NY   10017-3288
Tel: 212-986-3240 800-344-4867 (FIGHTMS)
Fax: 212-986-7981

American Autoimmune Related Diseases Association
22100 Gratiot Avenue
East Detroit, MI   48201-2227
Tel: 586-776-3900 800-598-4668
Fax: 586-776-3903

Source Public Domain

Back to the Free tips on Healthcare Homepage

Valid HTML 4.01! for Multiple Sclerosis


© Anthony George 2005 Multiple Sclerosis  Sponsor Love My Town